We gratefully acknowledge the The NSF (CAREER 1844443; 2019 – 2024) and the NIH (R35 GM137893-01; 2020 – 2025) for funding many aspects of our research program!
The Cope rearrangement!
We are developing a platform for chemical synthesis centered about a classic transformation
The project encompasses many of the hallmarks of organic synthesis; methods development, physical organic chemistry, computational chemistry, target synthesis (natural and unnatural products), and collaborative drug discovery.
Axially-chiral cannabinols!
We are developing a new class of cannabinoid for applications in drug discovery.
We have hypothesized that axially-chiral-cannabinols (ax-CBNs), unnatural and unknown isomers of cannabinol (CBN), may be valuable scaffolds for cannabinoid-inspired drug discovery. There are two main factors directing our interest to these scaffolds: (a) ax-CBNs would have ground-state three-dimensionality; ligand–receptor interactions can be more significant with complimentary 3D-topology, and (b) ax-CBNs at their core sare biaryl molecules, generally attractive platforms for pharmaceutical development due to their ease of functionalization and stability .